NMR Team Mackereth - Publications

Publications

Cameron Mackereth

Samir Amrane
Eric Largy
Gilmar Salgado

2024

Swain BC, Sarkis P, Ung V, Rousseau S, Fernandez L, Meltonyan A, Aho VE, Mercadante D, Mackereth CD, Aznauryan M. Disordered regions of human eIF4B orchestrate a dynamic self-association landscape. Nat. Commun. 15:8766
Kaiyum Y, Chao HP, Shoara AA, Nguyen M-D, Mackereth CD, Dauphin-Ducharme P, Johnson PE. 2024. Ligand-induced folding in a dopamine-binding aptamer. ChemBioChem (online ahead of print) DOI: 10.1002/cbic.202400493
Bellina A, Malfatti C, Salgado G, Fleming AM, Antoniali G, Gualandi N, La Manna S, Marasco D, Dassi E, Burrows CJ, Tell G. 2024. The apurinic/apyriminic endodeoxyribonuclease I is an RNA G-quadruplex binding protein and regulates miR-92b expression in cancer cells. bioRxiv
Rimbault C, Breillat C, Compans B, Toulme E, Vicente FN, Fernandez-Monreal M, Mascalchi P, Genuer C, Puente-Munoz V, Gautherau I, Hosy E, Giannone G, Chamma I, Mackereth CD, Pujol C, Choquet D, Sainlos M. 2024. Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes. eLife 13:e69620
De Rache A, Marquevielle J, Bouaziz S, Vialet B, Andreola ML, Mergny JL, Amrane S. 2024. Structure of a DNA G-quadruplex that modulates SP1 binding sites architecture in HIV-1 promoter. J. Mol. Biol. 436:168359

2023

Mondal S, Rousseau S, Talenton V, Thiam CAB, Aznauryan M, Mackereth CD. 2023. Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B. Biomol. NMR Assign. 17:199-203
Thore S, Raoelijaona F, Talenton V, Fribourg S, Mackereth CD. 2023. Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin. Open Biol 13:230221
Luo Y, Granzhan A, Marquevielle J, Cucciarini A, Lacroix L, Amrane S, Verga D, Mergny JL. 2023. Guidelines for G-quadruplexes: I. In vitro characterization. Biochimie 214:5-23
Santos T, Silva M, Imbert L, Campello MPC, Paulo A, Amrane S, Salgado GF, Cruz C, Cabrita EJ. Structural perspective into the interaction of an oncogenesis-relevant pre-miRNA G-quadruplex ligand carrier with the protein nucleolin. Chemistry 29:e202301181
Pachota M, Grzywa R, Iwanejko J, Synowiec A, Iwan D, Kaminska K, Skorenski M, Bielecka E, Szczubialka K, Nowakowska M, Mackereth CD, Wojaczynska E, Sienczyk M, Pyrc K. 2023. Novel inhibitors of HSV-1 protease effective in vitro and in vivo. Antiviral Res. 213:105604
Thore S, Fribourg S, Mackereth CD. 2023. ¹H, ¹⁵N and ¹³C resonance assignments of a minimal CPSF73-CPSF100 C-terminal heterodimer. Biomol. NMR Assign. 17:43-48

2022

Kabbara A, Vialet B, Marquevielle J, Bonnafous P, Mackereth CD, Amrane S. 2022. RNA G-quadruplex forming regions from SARS-2, SARS-1 and MERS coronaviruses. Front. Chem. 10:1014663.
Yoo SH, Buratto J, Roy A, Morvan E, Pasco M, Pulka-Ziach K, Lombardo CM, Rosu F, Gabelica V, Mackereth CD, Collie GW, Guichard G. 2022. Adaptive binding of alkyl glycosides by nonpeptidic helix bundles in water: toward artificial glycolipid binding proteins. J. Am. Chem. Soc. 144:15988-15998.
Malard F, Mackereth CD, Campagne S. 2022. Principles and correction of 5'-splice site selection. RNA biology 19:943-960.
Muthye VR, Mackereth CD, Stewart JB, Lavrov DV. 2022. Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function. DNA repair 110:103273.
Foucher AE, Touat-Todeschini L, Juarez-Martinez AB, Laroussi H, Karczewski C, Acajjaoui S, Lopez MS, Cusack S, Mackereth, CD, Verdel A, Kadlec J. 2022. Structural analysis of Red1 as a conserved scaffold of the RNA-targetting MTREC/PAXT complex. Nat. Commun. 13:4969.

2021

Collie GW, Lombardo CM, Pulka-Ziach K, Gabelica V, Mackereth CD, Rosu F, Guichard G. 2021. Crystal structures capture multiple stoichiometric states of an aqueous self-assembling oligourea foldamer. Chem. Commun. 57:9514-9517

2020

Upadhyay SK, Mackereth CD. 2020. Structural basis of UCUU RNA motif recognition by splicing factor RBM20. Nucleic Acids Res. 48:4538-4550.
Cheema MS, Good KV, Kim B, Soufari H, O'Sullivan C, Freeman ME, Stefanelli G, Casas CR, Zangeler KE, Kennedy AJ, Eirin Lopez JM, Howard PL, Zovkic IB, Shabanowitz J, Dryhurst DD, Hunt DF, Mackereth CD, Ausio J. 2020. Deciphering the enigma of the histone H2A.Z-1/H2A.Z-2 isoforms: novel insights and remaining questions. Cells. 9:1167.
Mateus P, Chandramouli N, Mackereth CD, Kauffmann B, Ferrand Y, Huc I. 2020. Allosteric recognition of homomeric and heteromeric pairs of monosaccharides by a foldamer capsule. Angew. Chem. Int. Ed. 58:5797-5805.

2019

Rimbault, C., Maruthi, K., Breillat, C., Genuer, C., Crespillo, S., Puente-Munoz, V., Chamma, I., Gauthereau, I., Antoine, S., Thibault, C., Tai, F.W.J., Dartigues, B., Grillo-Bosch, D., Claverol, S., Poujol, C., Choquet, D., Mackereth, C.D., Sainlos, M. 2019. Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules. Nat. Commun. 10:4521.
Jobin, M.L., Vamparys, L., Deniau, R., Grelard, A., Mackereth, C.D., Fuchs, P.F.J., Alves, I.D. 2019. Biophysical insight on the membrane insertion of an arginine-rich cell-penetrating peptide. Int. J. Mol. Sci. 20:E4441.
Post, S.R,, Langlois d'Estaintot, B., Granier, T., Mackereth, C.D., Fischer, L., Huc. I. 2019. Structure elucidation of helical aromatic foldamer-protein complexes with large contact surface areas. Chemistry 25:11042-11047.
Vallade, M., Jewginski, M., Fischer, L., Buratto, J., Bathany, K., Schmitter, J.-M., Stupfel, M., Godde, F., Mackereth, C.D., Huc. I. 2018. Assessing interactions between helical aromatic oligoamide foldamers and protein surfaces: a tethering approach. Bioconjugate Chem, 30:54-62.

2018

Baudin, A., Guichard, A., Collie, G.W., Rousseau, S., Chaignepain, S., Hocquellet, A., Berbon, M., Loquet, A., Mackereth, C., Guichard, G., Odaert, B . 2018. 1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD). Biomol. NMR Assign. 12:309-314.

2017

Dilworth, D., Upadhyay, S.K., Bonnafous, P., Edoo, A.B., Bourbigot, S., Pesek-Jardim, F., Gudavicius, G., Serpa, J., Petrotchenko, E., Borchers, C., Nelson, C.J., Mackereth, C.D. 2017. The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module. Nucleic Acids. Res. 45:11989-12004
Guéguéniat, J., Dupin, A., Stojko, J., Beaurepaire, L., Cianférani, S., Mackereth, C.D., Minvielle-Sébastia, L., Fribourg, S. 2017. Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3'-end processing. Nucleic Acids. Res. 45:10115-10131
Leung, A., Jardim, F.-P, Savic, N., Monneau, Y.R., Gonzalez-Romero, R., Gudavicius, G., Eirin-Lopez, J.M., Bartke, T., Mackereth, C.D., Ausio, J., Nelson, C.J. 2017. Basic surface features of nuclear FKBPs facilitate chromatin binding. Sci. Rep. 7:3795
Collie, G.W., Bailly, R., Pulka-Ziach, K., Lombardo, C.M., Mauran, L., Taib-Maamar, N., Dessolin, J., Mackereth, C.D., Guichard, G. 2017. Molecular recognition within the cavity of a foldamer helix bundle: encapsulation of primary alcohols in aqueous conditions. J. Am. Chem. Soc. 139:6128-6137
Jewginski, M., Granier, T., Langlois d'Estaintot, B., Fischer, L., Mackereth, C.D., Huc, I. 2017. Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries. J Am Chem Soc. 139:2928-2931
Soufari, H., Mackereth, C.D. 2017. Conserved binding of GCAC motifs by MEC-8, couch potato and the RBPMS protein family. RNA 23:308-316.

2016

Lombardo, C.M., Collie, G.W., Pulka-Ziach, K., Rosu, F., Gabelica, V., Mackereth, C.D., Guichard, G. 2016. Anatomy of an oligourea six-helix bundle. J. Am. Chem. Soc. 138:10522-10530.
Upadhyay, S.K. and Mackereth, C.D. 2016. 1H, 15N and 13C backbone and side chain resonance assignments of the RRM domain from human RBM24. Biomol. NMR Assign. 10:237-240.
Jewginski, M., Fischer, L., Colombo, C., Huc, I., Mackereth, C.D. 2016. Solution observation of dimerization and helix handedness induction in a human carbonic anhydrase-helical aromatic amide foldamer complex. ChemBioChem 17:727-736.

2015

Collie, G.W., Pulka-Ziach, K., Lombardo, C.M., Fremaux, J., Rosu, F., Decossas, M., Mauran, L., Lambert, O., Gabelica, V., Mackereth, C.D., Guichard, G. 2015. Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation. Nat. Chem. 7:871-878.
Xu, X., Perebaskine, N., Minvielle-Sébastia, L., Fribourg, S., Mackereth, C.D. 2015. Chemical shift assignments of a new folded domain from yeast Pcf11. Biomol. NMR Assign. 9:421-425.
Chandramouli, N., Ferrand, Y., Lautrette, G., Kauffmann, B., Mackereth, C.D., Laguerre, M., Dubreuil, D., Huc, I. 2015. Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose. Nat. Chem. 7:334-341.
Hennig, J., Warner, L.R, Simon, B., Geerlof, A., Mackereth, C.D., Sattler, M. 2015. Structural analysis of protein-RNA complexes in solution using NMR paramagnetic relaxation enhancements. Methods Enzymol.

2014

Mackereth, C.D. 2014. Splicing factor SUP-12 and the molecular complexity of apparent cooperativity. Worm. 3:e991240
Amrane, S., Rebora, K., Zniber, I., Dupuy, D., Mackereth, C.D. 2014. Backbone-independent nucleic acid binding by splicing factor SUP-12 reveals key aspects of molecular recognition. Nat. Commun. 5:4595.
Huang, J.-R., Warner, L.R., Sanchez, C., Gabel, F. Madl, T, Mackereth, C.D., Sattler, M., Blackledge, M. 2014. Transient electrostatic interactions dominate the conformational equilibrium sampled by multi-domain splicing factor U2AF65: A combined NMR and SAXS study. J. Am. Chem. Soc. 136:7068-7076
Amrane, S., Mackereth, C.D. 2014. Protein chemical shift assignments of the unbound and RNA-bound forms of the alternative splicing factor SUP-12 from C. elegans. Biomol. NMR Assign. 8:109-112.

2013

Monneau, Y.R., Soufari, H., Nelson, C.J., Mackereth, C.D. 2013. Structure and activity of the peptidyl-prolyl isomerase domain from the histone chaperone Fpr4 towards histone H3 proline isomerization. J. Biol. Chem. 288:25826-25837.
Gudavicius, G., Soufari, H., Upadhyay, S.K., Mackereth, C.D., Nelson, C.J.. 2013. Resolving the functions of peptidylprolyl isomerases: insights from the mutagenesis of the nuclear FKBP25 enzyme. Biochem. Soc. Trans. 41:761-768.

2012

Mackereth, C.D., Sattler, M. 2012. Dynamics in multi-domain protein recognition of RNA. Curr. Opin. Struct. Biol. 22:287-296
Monneau, Y.R, Nelson, C.J., Mackereth, C.D. 2012. Chemical shift assignments of the catalytic domain from the yeast proline isomerase Fpr4p. Biomol. NMR Assign. 6:123-126.

2011

Mackereth, C.D., Madl, T., Bonnal, S., Simon, B., Zanier, K., Gasch, A., Rybin, V., Valcárcel, J., Sattler, M. 2011. Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF. Nature 475:408-411
Moreno-Morcillo, M., Minvielle-Sébastia, L., Fribourg, S, Mackereth, C.D. 2011. Locked tether formation by cooperative folding of Rna14p monkeytail and Rna15p hinge domains in the yeast CF IA complex. Structure 19:534-545
Moreno-Morcillo, M., Minvielle-Sébastia, L., Mackereth, C., Fribourg, S. 2011. Hexameric architecture of CstF supported by CstF-50 homodimerization. RNA 17:412-418
Mackereth, C.D. 2011. Chemical shift assignments of a minimal Rna14p/Rna15p heterodimer from the yeast cleavage factor IA complex. Biomol. NMR Assign. 5:93-95

2010

Mourão, A., Varrot, A., Mackereth, C.D., Cusack, S., Sattler, M. 2010. Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX. RNA 16:1205-1216
Simon, B., Madl, T., Mackereth, C.D., Nilges, M., Sattler, M. 2010. An efficient protocol for NMR-based structure determination of protein complexes in solution. Angew. Chem. Int. Ed. Engl. 49:1967-1970

1998-2009

Kang, H.S., Nelson, M.L., Mackereth, C.D., Schärpf, M., Graves, B.J., McIntosh, L.P. 2008. Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha. J. Mol. Biol. 377:636-646
Soares, L.M., Zanier, K., Mackereth, C., Sattler, M. Valcárcel, J. 2006. Intron removal requires proofreading of U2AF/3' splice site recognition by DEK. Science 312:1961-1965
Macauley, M.S., Errington, W.J., Schärpf, M., Mackereth, C.D., Blaszczak, A.G., Graves, B.J., McIntosh, L.P. 2006. Beads-on-a-string: characterization of Ets-1 sumoylated within its flexible N-terminal sequence. J. Biol. Chem. 281:4164-4172
Wiesner, S., Hantschel, O., Mackereth, C.D., Superti-Furga, G., Sattler, M. 2005. NMR assignment reveals an alpha-helical fold for the F-actin binding domain of human Bcr-Abl/c-Abl. J. Biomol. NMR. 32:335
Mackereth, C.D., Simon, B., Sattler, M. 2005. Extending the size of protein-RNA complexes studied by nuclear magnetic resonance spectroscopy. ChemBioChem 6:1578-1584
Hantschel, O., Wiesner, S., Güttler, T., Mackereth, C.D., Remsing Rix, L.L., Mikes, Z., Dehne, J., Görlich, D., Sattler, M., Superti-Furga, G. 2005. Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl. Mol. Cell 19:461-473
Macauley, M.S., Errington, W.J., Okon, M., Schärpf, M., Mackereth, C.D., Schulman, B.A., McIntosh, L.P. 2004. Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. J. Biol. Chem. 279:49131-49137
Mackereth, C.D., Schärpf, M., Gentile, L.N., MacIntosh, S.E., Slupsky, C.M., McIntosh, L.P. 2004. Diversity in structure and function of the Ets family PNT domains. J. Mol. Biol. 342:1249-1264
Tognon, C.E., Mackereth, C.D., Somarsini, A.M., McIntosh, L.P., Sorensen, P.H. 2004. Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity. Mol. Cell. Biol. 24:4636-4650
Mackereth, C.D., Scharpf, M., Gentile, L.N., McIntosh, L.P. 2002. Chemical shift and secondary structure conservation of the PNT/SAM domains from the ets family of transcription factors. J. Biomol. NMR 24:71-72
Ramachander, R., Kim, C.A., Phillips, M.L., Mackereth, C.D., Thanos, C.D., McIntosh, L.P., Bowie, J.U. 2002. Oligomerization-dependent association of the SAM domains from Schizosaccharomyces pombe Byr2 and Ste4. J. Biol. Chem. 277:39585-39593
Slipetz, D., Buchanan, S., Mackereth, C.D., Brewer, N., Pellow, V., Hao, C., Adam, M., Abramovitz, M., Metters, K.M. 2001. Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor. Biochem. Pharmacol. 62:997-1012
Christendat, D., Yee, A., Dharamsi, A., Kluger, Y., Savchenko, A., Cort, J.R., Booth, V., Mackereth, C.D., Saridakis, V., Ekiel, I., Kozlov, G., Maxwell, K.L., Wu, N., McIntosh, L.P., Gehring, K., Kennedy, M.A., Davidson, A.R., Pai, E.F., Gerstein, M., Edwards, A.M., Arrowsmith, C.H. 2000. Structural proteomics of an archeon. Nat. Struct. Biol. 7:903-909
Mackereth, C.D., Arrowsmith, C.H., Edwards, A.M., McIntosh, L.P. 2000. Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum. Proc. Natl. Acad. Sci. USA 97:6316-6321
Slupsky, CM., Gentile, L.N., Donaldson, L.W., Mackereth, C.D., Seidel, J.J., Graves, B.J., McIntosh, L.P. 1998. Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site. Proc. Natl. Acad. Sci. USA 95:12129-12134


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